I have been experimenting with Posterous. It has a simple clean interface now and I like it!
With Posterous, you can simply email to register, and blog. Picture attachments can get resized or organised into a gallery while mp3s are embedded with a player. Comments can be managed entirely by email – i.e. when someone posts a comment that you want to respond to, just reply that email notification!
Take a look at my Posterous page and this post from Kenneth Pinto that explains more.